nur im Hochschulnetz
Background:
Glaucoma, a characteristic type of optic nerve degeneration in the posterior pole of the eye, is a common cause of irreversible vision loss and the second leading cause of blindness worldwide. As an optic neuropathy, glaucoma is identified by increasing degeneration of retinal ganglion cells (RGCs), with consequential vision loss. Current treatments only postpone the development of retinal degeneration, and there are as yet no treatments available for this disability. Recent studies have shown that replacing lost or damaged RGCs with healthy RGCs or RGC precursors, supported by appropriately designed bio-material scaffolds, could facilitate the development and enhancement of connections to ganglion cells and optic nerve axons. The consequence may be an improved retinal regeneration. This technique could also offer the possibility for retinal regeneration in treating other forms of optic nerve ailments through RGC replacement.
Methods:
In this brief review, we describe the innovations and recent developments in retinal regenerative medicine such as retinal organoids and gene therapy which are specific to glaucoma treatment and focus on the selection of appropriate bio-engineering principles, biomaterials and cell therapies that are presently employed in this growing research area.
Results:
Identification of optimal sources of cells, improving cell survival, functional integration upon transplantation, and developing techniques to deliver cells into the retinal space without provoking immune responses are the main challenges in retinal cell replacement therapies.
Conclusion:
The restoration of visual function in glaucoma patients by the RGC replacement therapies requires appropriate protocols and biotechnology methods. Tissue-engineered scaffolds, the generation of retinal organoids, and gene therapy may help to overcome some of the challenges in the generation of clinically safe RGCs.
Tagespflege in Bewegung
(2020)
Inside the “Sandbox”
(2022)
Interpretable neural networks based on continuous-valued logic and multicriteria decision operators
(2020)
Jugendhilfeplanung
(2020)
In dieser Arbeit finden sich Herleitungen und Verankerungen unserer aktuellen Menschenrechte, wie sie von den Vereinten Nationen festgehalten wurden. Besonders durch die Theorie von Silvia Staub-Bernasconi wird die Soziale Arbeit als Menschenrechtsprofession betrachtet. Diese Grundlagen werden in einen kurzen, sehr aktuellen, praktischen Anriss übertragen.
Innovation und Qualität
(2020)
Analyse der Wirksamkeit des Harninkontinenzmanagements in einer geriatrischen Rehabilitationsklinik
(2020)
Aus der Krise lernen
(2022)
Mobilitätshilfen sind allgegenwärtig und existenziell für Menschen, die aufgrund von Krankheit und Pflegebedürftigkeit in ihren Alltagsbewegungen und -fortbewegungen eingeschränkt sind. Mobilität steht in einem direkten Zusammenhang zur Selbstständig-keit und Selbstbestimmung im Alltag. Für viele pflegebedürftige Menschen sind Mobili-tätshilfen entscheiden dafür, ob sie ihren Alltag (wieder) selbst gestalten können. Dabei müssen sie sich innerhalb und außerhalb von Räumen ganz unterschiedlichen Heraus-forderungen stellen. Teilhabe am sozialen, möglicherweise auch am beruflichen Leben wird für viele Betroffene erst dann möglich, wenn die unterschiedlichen Mobilitätshilfen aufeinander und auf die jeweiligen Aktivitäten abgestimmt sind. Für Angehörige und für Pflegefachpersonen stellt sich täglich die Frage, mit welchen Mobilitätshilfen eine siche-re und angemessene Unterstützung möglich ist. Dabei gilt es, die Ausstattung mit Hilfen dem aktuellen Mobilitätsprofil der Betroffenen anzupassen; die Folgen von Über- oder Unterversorgung mit Mobilitätshilfen kann für die Betroffenen gravierende negative Folgen haben!
Alles, was Rollen hat
(2022)
"Schränkchen" im Wandel
(2023)
The objective of this study is to investigate the influence of veneering technique (hand-layering vs. milling) on the fracture resistance of bi-layer implant-supported zirconia-based hybrid-abutment crowns. Mandibular molar copings were anatomically designed and milled. Copings were then veneered by hand-layering (HL) (n = 20) and milling using the Cad-On technique (LD) (n = 20). Crowns were cemented to zirconia hybrid-abutments. Ten samples of each group acted as a control while the remaining ten samples were subjected to fatigue in a chewing simulator. Crowns were loaded between 50 and 100 N for 1.2 million cycles under simultaneous temperature fluctuation between 5 and 55 °C. Crowns were then subjected to static load a to fracture test. Data were statistically analysed using the one-way ANOVA. Randomly selected crowns from each group were observed under scanning electron microscopy to view fractured surfaces. Study results indicate that during fatigue, LD crowns had a 100% survival rate; while HL crowns had a 50% failure rate. Fracture resistance of LD crowns was statistically significantly higher than that of HL crowns at the baseline and after fatigue (p ≤ 0.05). However, fatigue did not cause a statistically significant reduction in fracture resistance in both LD and HL groups (p > 0.05). Copings fractured in the LD crowns only and the fracture path was different in both LD and HL groups. According to the results, it was concluded that milled veneer implant-supported hybrid-abutment crowns exhibit significantly higher fracture resistance, and better withstand clinical masticatory loads in the posterior region compared to the hand-layered technique. Also, fatigue application and artificial aging caused no significant strength reduction in both techniques. Clinical significance: Different veneering techniques and materials (hand-layering or milling) act differently to clinical forces and environment and may be prone to early chipping during service. Therefore, practitioners are urged to consider the appropriate veneering protocol for posterior implant-supported hybrid-abutment restorations.
Zum Beispiel Pflege – Fragen an den arbeitssoziologischen Topos der Subjektivierung von Arbeit
(2020)
Our current mobility paradigm increasingly faces economic, ecological, and social limits in urban areas. The aim of this paper is to analyse if a fleet of shared autonomous electric vehicles (AEVs) can meet these challenges while satisfying the current requirements of privately-owned internal combustion engine vehicles (ICEVs). Therefore, analytical models have been developed to simulate and investigate the impacts of mobility behaviour in Berlin and Stuttgart (Germany). The collected data were used to calculate the fleet size, the energy consumption, the emission of particulate matter, nitrogen oxides, and the carbon footprint of different shared AEVs in comparison with privately owned ICEVs. The approach shows that the system of a shared AEV fleet could lower externalities (accident avoidance, traffic jams, free spaces, parking costs and lifetime losses) in cities and generate cost benefits for customers.
Lasst uns nicht alleine!
(2020)