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In this chapter, to investigate the tensile behavior of CNTs, finite element models of single-walled carbon nanotubes (SWCNTs) in perfect and doped modes for common types of carbon nanotube (CNT) configuration, i.e., the armchair, zigzag, and chiral models, were generated using a commercial finite element software (MSC Marc). To create the computational models, nodes were placed at the locations of carbon atoms and the bonds between them were modeled using three-dimensional elastic generalized beam elements. Doped models were simulated by three different heteroatoms including silicon, nitrogen, and boron separately with the doping concentration ranging from 0 to 5%. Young’s moduli of all models were obtained and compared with the perfect structures. The results indicated that Young’s modulus of chiral SWCNTs is larger than the moduli of the armchair and zigzag SWCNTs in all models and incorporating the silicon and boron atoms into CNT led to a linear reduction in Young’s modulus which was most significant for silicon and less noticeable for boron. Regarding nitrogen doping, a different trend was observed that was a negligible and less conspicuous increment in the value of Young’s modulus by increasing the percentage of doping. Besides, this behavior was the same for all armchair, zigzag, and chiral configurations with the same dopant atom. The investigations also revealed that the structural irregularity and ripples, which are induced by dopant atoms, are a key factor which influences the tensile behavior of CNTs. Our results for Young’s modulus of doped CNTs are in good agreement with recent investigations.
This Encyclopedia covers the entire science of continuum mechanics including the mechanics of materials and fluids. The encyclopedia comprises mathematical definitions for continuum mechanical modeling, fundamental physical concepts, mechanical modeling methodology, numerical approaches and many fundamental applications. The modelling and analytical techniques are powerful tools in mechanical civil and areospsace engineering, plus in related fields of plasticity, viscoelasticity and rheology. Tensor-based and reference-frame-independent, continuum mechanics has recently found applications in geophysics and materials.
Background:
Glaucoma, a characteristic type of optic nerve degeneration in the posterior pole of the eye, is a common cause of irreversible vision loss and the second leading cause of blindness worldwide. As an optic neuropathy, glaucoma is identified by increasing degeneration of retinal ganglion cells (RGCs), with consequential vision loss. Current treatments only postpone the development of retinal degeneration, and there are as yet no treatments available for this disability. Recent studies have shown that replacing lost or damaged RGCs with healthy RGCs or RGC precursors, supported by appropriately designed bio-material scaffolds, could facilitate the development and enhancement of connections to ganglion cells and optic nerve axons. The consequence may be an improved retinal regeneration. This technique could also offer the possibility for retinal regeneration in treating other forms of optic nerve ailments through RGC replacement.
Methods:
In this brief review, we describe the innovations and recent developments in retinal regenerative medicine such as retinal organoids and gene therapy which are specific to glaucoma treatment and focus on the selection of appropriate bio-engineering principles, biomaterials and cell therapies that are presently employed in this growing research area.
Results:
Identification of optimal sources of cells, improving cell survival, functional integration upon transplantation, and developing techniques to deliver cells into the retinal space without provoking immune responses are the main challenges in retinal cell replacement therapies.
Conclusion:
The restoration of visual function in glaucoma patients by the RGC replacement therapies requires appropriate protocols and biotechnology methods. Tissue-engineered scaffolds, the generation of retinal organoids, and gene therapy may help to overcome some of the challenges in the generation of clinically safe RGCs.