In our present paper, we approach the mixed problem with initial and boundary conditions, in the context of thermoelasticity without energy dissipation of bodies with a dipolar structure. Our first result is a reciprocal relation for the mixed problem which is reformulated by including the initial data into the field equations. Then, we deduce a generalization of Gurtin’s variational principle, which covers our generalized theory for bodies with a dipolar structure. It is important to emphasize that both results are obtained in a very general context, namely that of anisotropic and inhomogeneous environments, having a center of symmetry at each point.